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But the progression of the disease can vary by individual, and not all people go through each stage (). The signature rash of a Lyme tick bite looks like a solid red oval or a bull’s-eye. The bull’s-eye has a central red spot, surrounded by a clear circle with a wide red circle on the outside. The rash is a sign that the infection is spreading within your skin tissues.Every individual reacts to the Lyme bacteria differently. The rash expands and then resolves over time, even if you’re not treated. The ticks in the nymph stage are the size of poppy seeds, and their bites are easy to miss.

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You may have stiffness and limited range of motion in some joints (1). Sometimes your knees may hurt, whereas other times it’s your neck or your heels. Bursae are the thin cushions between bone and surrounding tissue. About 50 percent of people with Lyme disease have flu-like symptoms within a week of their infection (18).

Thirty percent or more of people with Lyme disease don’t remember having the rash (). The initial red rash usually appears at the site of the bite within 3 to 30 days ().